Terra med Alliance Information Two Genes Cooperate To help Cause Aggressive Leukemia

Terra med Connections News: Two genes, all of which is known to cause cancer without treatment, together can lead in order to aggressive leukemia. This could be the conclusion from new research done on gene-modified mice with the Sahlgrenska Academy at your University of Gothenburg, Sweden. The particular discovery has surprised researchers, and may lead in order to new treatments. Terra med Connections News: The two genes can be present in mutated kind in acute leukemias, women and men mutations rarely occur jointly. Scientists have previously believed which the two mutated genes have the exact same function: each one alone will cause increased activity of a carcinogenic protein often known as "RAS. " This protein, sequentially, causes blood cells to proliferate faster. "This is a unusual discovery that suggests that we have a mechanism behind the development of cancer with which has not yet been recognized. It opens the way for new strategies of fighting blood cancer solar cells with NF1 mutations, " states Associate professor Martin Bergö, who leads the research with the Wallenberg Laboratory at the particular Sahlgrenska Academy. One from the genes codes for your RAS protein, which is usually a known accelerator for cell proliferation in a number of forms of cancer. Additional gene codes for a protein referred to as "NF1, " which may reduce the activity belonging to the RAS protein. The research group for the Sahlgrenska Academy has previously used two unique variations of mouse models, one ones with the RAS-mutation plus the other with the NF1-mutation. Both mutations individually produce a slowly progressing leukemia to develop while in the mice. The research group has now combined both animal models and shown which a very aggressive form connected with acute leukemia develops with mice with mutations both in genes. "The corresponding increase within the RAS signalling cannot describe the severe increase around disease aggressiveness, and which means the NF1 protein may play an alternative role in the introduction of the leukemia than we originally thought and probably do not involve the RAS protein in the least. The discovery opens an opportunity of developing new treatments for patients who've mutations in NF1, " states Martin Bergö. The research group is collaborating with another research group for the Sahlgrenska Academy, investigating the role the NF1 protein plays, and how these new results can result in new treatment strategies. Designed from materials provided by means of University of Gothenburg, by EurekAlert!,a service involving AAAS. Terra med Alliance can be a non-profit organization in your battle against leukemia helps children experiencing cancer and their people. Our goal is to assure children battling cancer know they may not be alone. For more tips please visit http: //www. terramedalliance. org. Contact at contact@terramedalliance. org